Dra. Claudia González Espinosa

 

PhD. Basic Biomedical Research, National Autonomous University of Mexico, 1995.

Post-doctoral training:

Cell Biology Department. Cell Physiology Institute, Natl. Autonomous Univ. Mexico City, Mexico, 1996-1998.

Molecular Inflammation Section. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH). Bethesda, Maryland, USA, 1999-2001.

Category. Titular Investigator (Cinvestav 3D)

National Investigators System Category. SNI III

Research lines

  • Signal transduction systems involved in the control of cytokine synthesis and secretion of pro-inflammatory and angiogenic mediators in mast cells.
  • Molecular mechanisms of inflammation, hypersensitivity and allergies.
  • Participation of mast cells distinct innate immune responses and angiogenesis.
  • Neuroendocrine control of mast cells-dependent immune reactions.

 

Representative Publications

*Mutant Huntingtin affects Toll-like receptor 4 intracellular trafficking and cytokine production in mast cells. Pérez-Rodríguez, M.J., Ibarra-Sánchez, A., Román-Figueroa, A., Pérez-Severiano, F., and González-Espinosa, C. Journal of Neuroinflammation, 2020.

 

* Mast cells localize in hypoxic zones of tumors and secrete CCL-2 under hypoxia through activation of L-type calcium channels. Ramírez-Moreno, I.G., Ibarra-Sánchez, A., Castillo-Arellano, J.I., Blank, U., and González-Espinosa, C. The Journal of Immunology, 204(4): 1056-1068, 2020. https://doi.org/10.4049/jimmunol.1801430

 

* TLR4 receptor induces 2-AG-dependent tolerance to Lipopolysaccharide and trafficking of CB2 receptor in mast cells. Espinosa-Riquer, Z., Ibarra-Sánchez, A., Vibhushan, S., Bratti, M., Charles, N., Blank, U., Rodríguez-Manzo, G., González-Espinosa, C. The Journal of Immunology, 202 (8):2360-2371, 2019. https://doi.org/10.4049/jimmunol.1800997

 

*Protein tyrosine kinase Fyn regulates TLR4-elicited responses on mast cells controlling the function of a PP2A/PKCα/β signaling node leading to TNF secretion. Martín-Ávila, A., Medina-Tamayo, J., Ibarra-Sánchez, A., Vázquez-Victorio, G., Castillo-Arellano, J..I., Hernández-Mondragón, A.C., Rivera, J., Madera-Salcedo, I.K., Blank, U., Macías-Silva, M., González-Espinosa, C. J. Immunol 196:5075-5088, 2016.

 

* Madera-Salcedo, I., Cruz, S., González-Espinosa, C. Morphine prevents lipopolisaccharide-induced TNF secretion in mast cells blocking IkB kinase activation and SNAP-23 phosphorylation: correlation with the formation of a b-arrestin/TRAF6 complex. J Immunol. 191(6):3400-3409, 2013.

 

* Jiménez-Andrade, GY., Ibarra-Sánchez, A., González, D., Lamas, M., González-Espinosa, C. Immunoglobulin E induces VEGF production in mast cells and potentiates their pro-tumorigenic actions through a Fyn kinase-dependend mechanism. J. Hematol Oncol 6 (1): 56- 69, 2013.

 

* Sanchez-Miranda, E., Ibarra-Sánchez, A., González-Espinosa, C. Fyn kinase controls FceRI receptor-operated calcium entry necessary for full degranulation in mast cells. Biochem. Biophys. Res. Commun. 391:1714-20, 2010.

 

González-Espinosa, C., Odom, S., Olivera, Hobson, A, Cid, ME., Siegel, S., Penninger, J; Rivera, J. Preferential signaling and induction of selected allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells. The Journal of Experimental Medicine.197:1453-1465, 2003.

 


 


Laboratory 11

Phone. +52(55)5483-2875
Fax +52(55)5483-2863
E-mail: cgonzal@cinvestav.mx