Dr. Vinicio Granados Soto

 

Dr. Vinicio Granados-Soto

Neurobiology of Pain Laboratory (Lab. 12)

Position: Full professor

BSc: Chemistry, Universidad Michoacana de San Nicolás de Hidalgo. Morelia, Michoacán, 1988.

MSc: Pharmacology, Department of Pharmacology and Toxicology, Cinvestav, 1991.

PhD: Pharmacology, Department of Pharmacology and Toxicology, Cinvestav, 1994.

Postdoc: Department of Anesthesiology, UCSD, USA, 1997-1998.

Visiting Professor: Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán. 2002-2003.

Visiting Professor: Department of Pharmacology, Ribeirão Preto School of Medicine, University of São Paulo, Brazil. 2012-2013.

National Researchers System: Level 3

Production

Articles

165

Chapters 

6

National and international meetings

240

 

Supervision of students

B.Sc.

  11

M.Sc.        

  28

Ph.D.

  19

 

Research lines

Our group examines the neurobiology of peripheral and spinal systems that regulate transmission of nociceptive information. Our laboratory is interested in the trigger mechanisms of pain at peripheral and central levels. Moreover, our laboratory is interested in studying the mechanisms which drive hyperalgesia and allodynia in several preclinic pain models (inflammatory, neuropathic and dysfunctional). Lab approaches include behavioral analysis of pain, as well as molecular biology (Western-blot and qPCR), histology (immunohistochemistry) and ELISA.

Relevant discoveries related with these research lines

1) Our findings suggest that diabetic pain is related to the generation of methylglyoxal which then activate the stress integrated response to induce pain.

2) Our findings suggest that aGABAA receptors could be a target to develop safer and effective analgesic in women.

3) Our data indicate that viruses, besides infection, induce pain through production of type 1 interferon.

4) We have developed models of pain related with prediabetes and diabetes. These models are useful to understand diabetic pain. 

 

Publications related with these research lines

* Franco-Enzástiga Ú, García G, Murbartián J, González-Barrios R, Salinas-Abarca AB, Sánchez-Hernández B, Tavares-Ferreira D, Herrera LA, Barragán-Iglesias P, Delgado-Lezama R, Price TJ, Granados-Soto V. Sex-dependent pronociceptive role of spinal a5-GABAA receptor and its epigenetic regulation in neuropathic rodents. Journal of Neurochemistry 156(6): 897-916, 2021. doi: 10.1111/jnc.15140.

* Barragán-Iglesias P, Franco-Enzástiga Ú, Jeevakumar V, Shiers S, Wangzhou A, Granados-Soto V, Campbell ZT, Dussor G, Price TJ. Type I interferons act directly on nociceptors to produce pain sensitization: Implications for viral infection-induced pain. Journal of Neuroscience 40(18): 3517-3532, 2020. doi: 10.1523/JNEUROSCI.3055-19.2020.

* Barragán-Iglesias P, Kuhn J, Vidal-Cantú GC, Salinas-Abarca AB, Granados-Soto V, Dussor GO, Campbell ZT, Price TJ. Activation of the integrated stress response in nociceptors drives methylglyoxal-induced pain. Pain 160(1): 160-171, 2019. doi: 10.1097/j.pain.0000000000001387.

* Bravo-Hernández M, Corleto JA, Barragán-Iglesias P, González-Ramírez R, Pineda-Farias JB, Felix R, Calcutt NA, Delgado-Lezama R, Marsala M, Granados-Soto V. The a5 subunit-containing GABAA receptors contribute to chronic pain. Pain 157(3): 613-626, 2016. doi: 10.1097/j.pain.0000000000000410.

Current projects

1) Participation of spinal a6 GABAA receptors in neuropathic pain in rodents.
2) Study of the dopaminergic system in a fibromyalgia-type pain in rats.
3) Involvement of toll type receptors (TLR2, TLR4, TLR5 and RAGE) in several models of fibromyalgia in rats.
4) Pharmacological activity of cannabidiol on PPARg and GPR55 receptors in a model of neuropathic pain in mice.
5) Study of the thioctic acid’s mechanism of action on methylglyoxal-induced pain in mice. 

Former lab members

         Name                                                          Current position

Gerardo Reyes-García                         Professor, Escuela Superior de Medicina, IPN

Jorge Elías Torres-López                      Professor, UJAT, Villahermosa, Tabasco

Mario I. Ortiz Ramírez                          Professor, UAEH, Pachuca, Hidalgo

Teresa Mixcoatl-Zecuatl                       Not determined

Nadia Lizeth Caram-Salas                    Professor, CISESE, Ensenada, Baja California

Deysi Yadira Bermúdez-Ocaña             Professor, UJAT, Comalcalco, Tabasco

Fernando Ortega-Varela                       Professor, UMSNH, Morelia, Michoacán

Mónica Ambriz-Tututi                            Professor, Hospital General Ajusco Medio, CDMX

Héctor Isaac Rocha-González               Professor, ESM-IPN, CDMX

Claudia Ivonne Araiza-Saldaña             Professor, UJAT, Villahermosa, Tabasco

Gabriela Castañeda-Corral                   Professor, Facultad de Medicina. UAEMor, Cuernavaca

Beatriz Godínez-Chaparro                    Professor, UAM-Xochimilco, CDMX

Claudia Cervantes-Durán                     Postdoc, UMSNH, Morelia, Michoacán

Paulino Barragán-Iglesias                     Professor, Universidad Autónoma de Aguascalientes

Jorge Baruch Pineda-Farias                  Postdoc, University of Pittsburgh, PA

Mariana Bravo-Hernández                   Postdoc, UCSD, San Diego, CA

Ana Elena Lemus-Castellanos              Study Management Associate, ICON Clinical Research

Ana Belen Salinas-Abarca                     Postdoc, Instituto de Neurobiología, UNAM, Juriquilla

Úrzula Monserrat Franco-Enzástiga    Postdoc, University of Texas, Dallas

Facebook: https://www.facebook.com/Labdolorcinvestav/

Tel. +52-55-5483-2868 (Ofic.), +52-55-5483-2800 Ext 1222 (Lab)
Fax +52-55-5483-2863
E-mail: vgranados@cinvestav.mx