Dr. Francisco Javier López Muñoz

PhD: Pharmacology, Departamento de Farmacología y Toxicología, Centro de Investigación y de Estudios Avanzados . México 1992.

M. Sc.: Pharmacology, Departamento de Farmacología y Toxicología, Centro de Investigación y de Estudios Avanzados. México 1986.

B.Sc.: Pharmaceutical Chemist. & Biologist  (Q.F.B.), Universidad Autónoma de Puebla. México 1982.

Current position: Professor “3C” at the Pharmacobiology Department. Center for Research and Advanced Studies. Mexico, D.F.

Member of the National System of Researchers (SNI): Level III

  • Papers in refereed journals: 105
  • Chapters in books: 4
  • Congress communications: 230

Direction of research projects for theses:

Bachelor 16
Master in Sc. 24
Ph.D. 14


Lines of Research:

  • Pharmacodynamia and  pharmacokinetic of analgesic drugs
  • Analgesic interaction, potentation and synergism between analgesic and adjuvant drugs. Analysis of type “Surface of synergistic interaction”
  • Determination of the optimal ratio of drug combination that produce high degree of potentiation or the highest antinociceptive effect and without increase in side effects
  • Enhancement of antinociception by co-administration of adjuvants (5HT, histamine, adrenergic substances, nitric oxide, gabapentin)
  • Pain: mechanisms and  treatment
  • Experimental models to assess analgesic activity
  • Screening and evaluation of medicinal plants or synthetic compounds for the treatment of pain
  • Analgesic tolerance.

Some publications:

* "Antinociceptive effects of tramadol in co-administration with metamizol after single and repeated administrations in rats”. LA Moreno-Rocha, AM Domínguez-Ramírez, AR Cortés-Arroyo, G Bravo, FJ López-Muñoz. Pharmacol Biochem & Behav 103:1-5, 2012.

* “Antinociceptive and anti-inflammatory activities of the Agastache mexicana extracts by using several experimental models in rodents”. A González-Ramírez, ME González-Trujano, F Pellicer, FJ López-Muñoz. J Ethnopharmacology 142:700-705, 2012.

* “Insular cortex lesion diminishes neuropathic and inflammatory pain-like bahaviours“. Coffeen U, JM Ortega-Legaspi, FJ López-Muñoz, K Simon-Arceo, O Jaimes, F Pellicer. Eur J Pain 15: 132-138, 2011.

* “Effect of metamizol on morphine pharmacokinetics and pharmacodynamics after acute and subchronic administration in arthritic rats”. Domínguez-Ramírez AM, AR Cortés-Arroyo, MH Y de la Peña, JR Medina, FJ López-Muñoz. Eur J Pharmacol 645:94-101,  2010.

* “Anti-nociceptive synergism of morphine and gabapentin in neuropathic pain induced by chronic constriction injury”. De la O-Arciniega M, MI Díaz-Reval, AR Cortés-Arroyo, AM Domínguez-Ramírez, FJ López-Muñoz. Pharmacol Biochem & Behav 92:457-464, 2009.


Participation in boards/committees:

Referee of papers submitted to the following journals:

Drugs Evaluation, Medical Sciences Monitor, Pharmacological Research, Life Sciences, European Journal of Pain, European Journal of Pharmacology, Journal of Ethnopharmacology,  Pharmacology Biochemistry & Behavior, Archives of Medical Research, Hormone & Metabolic Research, Revista Mexicana de Anestesiología, Neuroscience Letters, Journal of Pharmacy & Pharmacology.

Laboratory 7

Phone: +52(55)5483-2851
Fax +52(55)5483-2863
E-mail: flopezm@prodigy.net.mx, flopez@cinvestav.mx