Dr. David Centurión Pacheco

Postdoctoral Research Fellow. Department of Pharmacology, Royal Free Campus, University College London. United Kingdom, 2000-2001.

Ph.D.: Pharmacology, Department of Pharmacology and Toxicology, Cinvestav, September, 2000.

M.Sc.: Pharmacology, Department of Pharmacology and Toxicology, Cinvestav, December, 1997.

B.Sc.: Universidad Autónoma de Campeche, May, 1995.

Current position: Associate professor.

Research interests

*     Pharmacological characterization of the cardiovascular responses to catecholamines, imidazolines and sex steroids (estradiol and testosterone).
*     Mechanisms involved on: (1) the modulation of the cardiovascular sympathetic outflow; and (2) the contractile responses of several vasoactive compounds.
*     Protective effect of sex steroids in the cardiovascular system in experimental models of Diabetes Mellitus and hypertension.
*    Pharmacological characterization of the cardiovascular effects of hydrogen sulphide (H2S), a gasotransmitter with cardioprotector and vasculoprotector properties.

 

Experimental models

·        Pithed rat
·        Isolated blood vessels from several species
·        Type 1 and Type 2 Diabetes Mellitus and Hypertension

 

Scientific productivity

Peer-reviewed articles: 75
Book chapters: 3
Meeting abstracts: 150

 

Supervision of thesis

Ph. D.: 6
M. Sc.: 16

B. Sc.: 7

Supervisor of summer undergraduate research program since 2003-2019: 17 students


Representative publications

*Huerta de la Cruz, S., Rocha, L., Santiago-Castañeda, C., Sánchez-López, A., Pinedo-Rodríguez, A.D., Medina-Terol, G.J., Centurión, D. NaHS subchronic treatment improves hypertension induced by traumatic brain injury in rats through vasopressor sympathetic outflow inhibition. Journal of Neurotrauma. Accepted. 2021. https://doi.org/10.1089/neu.2020.7552 

*Cortes-López, F., Sánchez-Mendoza, A., Centurión, D., Cervantes-Pérez, L.G., Castrejon-Téllez, V., Valle-Mondragon, L., Soria-Castro, E., Ramirez, V., Sánchez-López, A., Pastelin-Hernández, G., Garcia-Niño, W.R., Sánchez-Aguilar, M., Ibarra-Lara L. Fenofibrate Protects Cardiomyocytes from Hypoxia/Reperfusion- and High Glucose-Induced Detrimental Effects. PPAR Research. Article ID 8895376, 15 pages. 2021. https://doi.org/10.1155/2021/8895376 . Tesis de maestría de Fabiola Cortés López.

*Solís-Guillén, R., Leopoldo, M., Meneses, A., Centurión, D. Activation of 5-HT1A and 5-HT7 receptors enhanced a positively reinforced long-term memory. Behavioural Brain Research. 397, 112932. 2021. https://doi.org/10.1016/j.bbr.2020.112932. Tesis de doctorado de Rocío del Carmen Solís Gullén).

* Gomez, C.B., Huerta de la Cruz, S., Medina-Terol, G.J., Beltrán-Ornelas, J.H., Sánchez-López, A., Silva-Velasco, D.L., Centurión, D. Chronic administration of NaHS and L-Cysteine restores cardiovascular changes induced by high-fat diet in rats. European Journal of Pharmacology. In press. Doi: https://doi.org/10.1016/j.ejphar.2019.172707 (Tesis de Maestría de Carolina Belen Gomez). 

 

* Álvarez-Cámara, J.F., Ramírez-Rosas, M.B., Medina-Terol, G.J., Silva-Velasco, D.L., Velazco-Paz, A., Sánchez-López, A., Guzman-Priego, C.G., Osuna-Martinez, U., Centurión, D., 2019. Potential vascular α1-adrenoceptor blocking properties of metformin in rat aorta and tail artery. European Journal of Pharmacology. 858C, 172498. Doi: https://doi.org/10.1016/j.ejphar.2019.172498 (Tesis de Licenciatura de José Francisco Álvarez Cámara).

 

* De la Cruz, S.H., Medina-Terol, G.J., Beltrán-Ornelas, J.H., Gomez, C.B., Morato-Valderrama, Y., Sánchez-López, A., Centurión, D., 2018. Pharmacological evidence that metformin blocks the vasopressor responses mediated by stimulation of α1- and α2- adrenoceptors in pithed rats. European Journal of Pharmacology. 820, 130-137. Doi: https://doi.org/10.1016/j.ejphar.2017.12.032 (Tesis de Licenciatura de Grecia Josefa Medina Terol).

 

* Gutiérrez-Lara, EJ., Navarrete-Vázquez, G., Sánchez-López, A. & Centurión, D. Pharmacological evaluation of metformin and N-  benzylbiguanide, a novel analogue of metformin, on the vasopressor responses to adrenergic system stimulation in pithed rats with  fructose-induced insulin resistance. European Journal of Pharmacology.  814: 313-323. 2017. Doi:  http://dx.doi.org/10.1016/j.ejphar.2017.08.044 (Tesis de Doctorado de Erika Joana Gutiérrez Lara)

 

 

Distinctions

*  Keith and Eva Killam Memorial Award 2009. This award, originally offered as the Syntex Prize, was created by the Western Pharmacology Society to recognize important contributions by young investigators in pharmacology.

*  Premio Nacional Jaime Herrera 2006” awarded by the Society of Arterial Hypertension of Mexico in basic research with the work derived from M. Sc. thesis of Elsa B. Monroy-Ordoñez “Pharmacological characterization of the mechanisms involved on the inhibition by several imidazolines on the vasopressor responses induced by sympathetic stimulation in pithed rats”.

*  Speaker in several international symposia within international congresses that have taken place in Japan, England, Portugal, Denmark, Argentina and Mexico.

 

Reviewer in the following indexed journals:

 

1.    British Journal of Pharmacology

2.    PlosONE

3.    European Journal of Pharmacology

4.    Journal of Cardiovascular Pharmacology

5.    Naunyn-Schmiedebergs’s Archives of Pharmacology

6.    Journal of Pharmacological Sciences

7.    Brain Research

 

 

 

Facebook: https://www.facebook.com/lab6cinvestavsedesur/

 

 

Assistant

Araceli Sánchez-López, Ph.D.
Laboratory 6
Phone: +52 (55) 5483 2866
Fax +52 (55) 5483 2863
e-mail: arycinvestav@gmail.com