• 21 / 06 / 2018
Cinvestav - Centro de Investigación y de Estudios Avanzados del I.P.N.

Dr. Vinicio Granados Soto

Visiting Professor: Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brasil. 2012-2013.
Post-doctoral research fellow: Department of Anesthesiology, University of California, San Diego, USA, 1997-1998.
Ph.D. Degree: Pharmacology, Departamento de Farmacología y Toxicología, Centro de Investigación y de Estudios Avanzados del I.P.N. México, D.F., México, 1994.
M.Sc. Degree: Pharmacology, Departamento de Farmacología y Toxicología, Centro de Investigación y de Estudios Avanzados del I.P.N. México, D.F., México, 1991.
B.Sc. Degree: Pharmacist Escuela de Químico-Farmacobiología de la Universidad Michoacana de San Nicolás de Hidalgo. Morelia, Mich., Mexico, 1988.
Current Position: Full Professor.
Member of the National System of Researchers (SNI): Level 3


Articles in peer-reviewed journals 150
Chapters in books 5
National and international meetings 230


Supervision of thesis:

B.Sc.   11
M.Sc.           23
Ph.D.   17


Research interests:

Our group examines the neurobiology of the peripheral and central systems that regulate the sensory nociceptive processing (pain). We are interested in studying the role of receptors and mechanisms, which lead to pain in primary afferent neurons and spinal cord.

In addition, our group is interested in studying the mechanisms that produce hyperalgesia and allodynia in experimental diabetes. Also, we study the peripheral and central mechanisms that produce inflammatory and neuropathic pain.

The experimental approach of our lab includes behavioral analysis as well as molecular biology techniques (Western blotting and PCR), histology (immunohistochemistry) and ELISA.

Recent publications:

* Hernández-León A, De la Luz-Cuellar YE, Granados-Soto V, González-Trujano ME, Fernández-Guasti A. Sex differences and estradiol involvement in hyperalgesia and allodynia in an experimental model of fibromyalgia. Hormones and Behavior 97: 39-46, 2018.

* Bravo-Hernández M, Corleto JA, Barragán-Iglesias P, González-Ramírez R, Pineda-Farias JB, Felix R, Calcutt NA, Delgado-Lezama R, Marsala M, Granados-Soto V. The α5 subunit-containing GABAA receptors contribute to chronic pain. Pain 157(3): 613-626, 2016.

* Lopez-Canul M, Palazzo E, Dominguez-Lopez S, Luongo L, Lacoste B, Comai S, Angeloni D, Fraschini F, Boccella S, Spadoni G, Bedini A, Tarzia G, Maione S, Granados-Soto V, Gobbi G. Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways. Pain 156(2): 305-317, 2015.

* Pineda-Farias JB, Barragán-Iglesias P, Loeza-Alcocer E, Torres-López JE, Rocha-González HI, Pérez-Severiano F, Delgado-Lezama R, Granados-Soto V. Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats. Molecular Pain 11:41, 2015.
* Barragán-Iglesias P, Pineda-Farias JB, Cervantes-Durán C, Bravo-Hernández M, Rocha-González HI, Murbartián J, Granados-Soto V. Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells. Molecular Pain 10: 29, 2014.

* Ambriz-Tututi M, Granados-Soto V. Oral and spinal melatonin reduces tactile allodynia in rats via activation of MT2 and opioid receptors. Pain 132: 273-280, 2007.

* Granados-Soto V, Kalcheva I, Hua XY, Newton A, Yaksh TL. Spinal PKC activity and expression: Role in tolerance produced by continuous spinal morphine infusion. Pain 85 (3): 99-104, 2000.



Frequent referee of papers submitted to the following indexed journals:

1) Acta Anaesthesiologica Scandinavica; 2) Acta Pharmacologica Sinica; 3) Anesthesia and Analgesia; 4) Basic and Clinical Pharmacology and Toxicology; 5) BMC Neuroscience; 6) Brain Research Bulletin; 7) British Journal of Pharmacology; 8) Clinical and Experimental Pharmacology and Physiology 9) CNS Neuroscience and Therapeutics; 10) Current Medical Research and Opinion; 11) Current Neuropharmacology; 12) European Journal of Pain; 13) European Journal of Pharmacology; 14) Evidence-Based Complementary and Alternative Medicine; 15) Experimental and Molecular Pathology; 16) Expert Opinion on Therapeutic Targets; 17) Food and Chemical Toxicology; 18) Frontier in Integrative Neuroscience; 19) Fundamental and Clinical Pharmacology; 20) Indian Journal of Pharmacology; 21) Japanese Journal of Pharmacology; 22) Journal of Basic and Clinical Physiology and Pharmacology; 23) Journal of Cellular Physiology; 24) Journal of Clinical Medicine and Research; 25) Journal of Neuroinflammation; 26) Journal of Pain; 27) Journal of Pain Research; 28) Journal of Pharmacy and Pharmacology; 29) JoVE; 30) Life Sciences; 31) Medicinal Chemistry; 32) Metabolic Brain Disease; 33) Molecular Pain; 34) Naunyn-Schmiedeberg Archives of Pharmacology; 35) Neuropharmacology; 36) Neuroscience; 37) Neuroscience Letters; 38) Neurosignals; 39) Nutrition; 40) Open Journal of Pharmacology; 41) Pain; 42) Pain Research and Treatment; 43) Pharmacology Biochemistry and Behavior; 44)  Pharmacological Reports; 45) Plos One; 46) Purinergic Signalling; 47) Scientific Reports.


Some honours / distinctions


  • More than 130 papers published in indexed international journals. These papers have been quoted more than 2000 times in other publications in international indexed journals (excluding self-quotations).
  • The Keith F. Killam Jr. Memorial Award in Pharmacology, awarded by the Western Pharmacology Society in 2006.


Laboratory 12

Research support:

Guadalupe Concepción Vidal Cantú (e-mail: gvidal@cinvestav.mx )

M.Sc. Students:

Erik Josué Rodríguez Palma (ejosue26@hotmail.com)

Erika Curiel Gómez (erika.curiel.g@gmail.com)

Alejandro Pluma Pluma (alexppdf@gmail.com)

Iker P. Pérez García (ikerparis1@gmail.com)

Ph.D. Students:

Ana Belén Salinas-Abarca (e-mail: absa.belen@gmail.com)

Urzula M. Franco Enzastiga (e-mail: urzzula_franco@hotmail.com)

Yarim E De la luz Cuellar (atarii.yc@gmail.com)


Former Lab members:

Name Current position
Gerardo Reyes-García Professor, Escuela Superior de Medicina, IPN
Jorge E. Torres-López  Professor, UJAT, Villahermosa, Tabasco
Mario I. Ortiz Professor, UAEH, Pachuca, Hidalgo
Teresa Mixcoatl-Zecuatl Indeterminate
Nadia L. Caram-Salas Professor, INECOL, Xalapa, Veracruz
Deysi Y. Bermúdez-Ocaña Researcher, Hospital "Dr. Gustavo A. Rovirosa Pérez"
Fernando Ortega-Varela Professor, UMSNH, Morelia, Michoacán
Mónica Ambriz Tututi Professor, Hospital General Ajusco Medio, México D.F.
Héctor I. Rocha González
Professor, ESM-IPN, México, DF
Claudia I. Araiza Saldaña
Professor, UJAT, Villahermosa, Tabasco
Gabriela Castañeda Corral School of Medicinedoc, UAE, Mor.
Beatriz Godinez Chaparro Department of biological systems DCBS, UAM-Xochimilco
Claudia Cervantes Durán Postdoc, UMSNH, Morelia, Michoacán
Paulino Barragán-Iglesias Posdoc, University of Texas, Dallas
Jorge Baruch Pineda-Farias Posdoc, University of Pittsburgh,PA
Mariana Bravo-Hernández Posdoc, UCSD, CA
Ana Elena Lemus Castellanos Study Management Associate, ICON Clinical Research, México


Tel. +52-55-5483-2868 (Ofic.), +52-55-5483-2800 Ext 1222 (Lab)
Fax +52-55-5483-2863
E-mail: vgranados@cinvestav.mx

Cinvestav | Centro de Investigación y de Estudios Avanzados del I.P.N.
Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, C.P. 07360 México, D.F. Apartado postal: 14-740, 07000 México, D.F.
Teléfono: 5747 3800
www.cinvestav.mx | Privacy Statement | Terms Of Use | Copyright 2018 by DNN Corp